A new study highlights the development of curcumin-loaded polymeric nanoparticles for the treatment of Dry Eye Disease (DED)—and prominently features the ShearJet® HL 60 high-pressure homogenizer as an essential tool in the process. Leveraging the precise controls of the HL 60, the research team achieved an optimized nanoparticle size of 170.2 nm, with a PDI of 0.341 and 90% entrapment efficiency.
Published in the Journal of Drug Delivery Science and Technology, the investigation demonstrated that these nanoparticles achieved sustained drug release, enhanced tear secretion, and contributed to maintaining corneal structure in ex vivo testing—supporting their potential for in vivo application. The study combined curcumin with HPMC and Poloxamer 407 using high-pressure homogenization, demonstrating how the HL 60 supports uniform particle production and size control for opthalmic nanosuspension development.